AKIPRESS.COM - After a night of no sleep, even a healthy brain has higher than normal levels of the protein that forms the signature tangles in Alzheimer’s disease, according to a new study from the Netherlands.

“We think normal healthy sleep helps reduce the amount of (amyloid) beta in the brain and if your sleep is disturbed this decrease is prevented,” said the study’s senior author Dr. Jurgen Claassen, from Radboud University Medical Center in Nijmegen.

In people who repeatedly fail to get a good night's sleep, the amyloid-beta concentration may build up and could be one factor in the development of Alzheimer’s disease, he said, NY Daily News reported.

Alzheimer’s is the most common form of dementia and the sixth leading cause of death for older Americans, according to the Centers for Disease Control and Prevention. Up to 5 million Americans have the condition.

Distinct from other forms of dementia, Alzheimer’s is partly defined by accumulations in the brain of the amyloid-beta protein. The cause of Alzheimer’s disease is not known, but the amyloid-beta plaques have long been thought to play an important role.

Claassen and his colleagues point out in JAMA Neurology that studies on mice have found decreases in the amount of amyloid-beta in healthy animals’ brains after a good night’s sleep. That suggests sleep plays a role in cleaning out the protein overnight.